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Department of Molecular and Cellular Biochemistry

The department of biochemistry was founded by Professor Yoshihiro Takeda in 1959 and has largely contributed to development of life sciences, medical and dental sciences. The department of biochemistry has produced many talented and excellent researchers, educators and dentists one after another from starting a course. We are currently focusing on the cancer biology and the bone metabolism and leading the fields in Japan and the world.


E-mail (below@, dent.osaka-u.ac.jp)
Riko Nishimura
Associate Professor
Kenji Hata
Associate Professor
Tomohiko Murakami
Assistant Professor
Yoshifumi Takahata

Research Activities

"Bone" functions not only as skeletal and locomotive organs but also "Internal organs" that regulate metabolisms of calcium and phosphate, produce hormone such as FGF23 and osteocalcin and associates with hematopoiesis and angiogenesis. Moreover, bone contains various different types of cells including immune cells, hematopoietic cells, neuronal cells and adipocytes in addition to skeletal cells including osteoclasts, osteoblasts, osteocytes and chondrocytes, and thus, bone forms a very complex but well-organize cellular network system. Since the super-aged society is now approaching in Japan, an increase of the disease rate of locomotive syndrome such as osteoporosis, osteoarthritis and the rheumatoid arthritis has become a big social problem. More importnatly, the bone metastasis of the malignant tumors such as breast and prostate cancers is greatly closed up and a great issue. Because bone is an essential tissue to support teeth, investigation of bone biology is also very important in dental field. Development of regeneration of bone tissues in jaws sheds lights on bone destruction by periodontitis and the successful achievement of dental implant. Our goal of the research contributes to development of effective therapy on bone diseases.
To approach this goal, we are investigating bone and cartilage biology at cellular and molecular level by using latest techniques of molecular biology and genetic approaches. Our aims are to examine 1. The molecular mechanisms regulating metastasis malignant tumors into bone, 2. The mechanisms of osteoblast differentiation and bone formation 3. The mechanisms of osteoclast differentiation and bone resorption 4. The mechanisms of endochondral ossification. These studies are published in the top-level international scientific journals and received high appraisal from the inside and the outside countries. To organically and dynamically advance both education and research systems, we have several constructive collaborations with creative and productive laboratories, domesticaly and internationally. We have invited outstanding researchers from domestic and foreign countries and organized many attractive seminars by them. Furthermore, we have attempted to encourage young scientists to study in the outstanding laboratory in the world. Our laboratory is eager to promote young scientists to those who play an active role in the world and actually, a lot of graduate students and postdoctoral fellows won the authoritative prizes and fellowships from international scientific society.

Department of Molecular and Cellular Biochemistry