Department of Pharmacology

We are investigating mechanisms of various molecules and drug actions for the application to novel and better drug therapies in our Department. We have now 12 staffs and members under the supervision of Professor Yoshinori Kamisaki.


Staff

position
name
E-mail (below@, dent.osaka-u.ac.jp)
Professor
Kazuhiro Takuma
Associate Professor
Takanobu Nakazawa
Assistant Professor
Yasuhiro Ohi

Research Activities

Research Activities

The main themes of our Department are to investigate the mechanisms of “Inflammation and Pain”. Inflammation and pain are common warning and protective reaction against various harmful stimulants. However, excessive reactions of inflammation and pain are sometimes required to be suppressed by various drugs. We are trying to clarify the detailed mechanisms of the developments of inflammation and pain in order to control such excessive reactions. Various molecules are involved in the development of inflammation and pain. Among them, nitric oxide is unique molecule on regulation of various physiological functions such as vascular dilation and inflammation. We reported new regulatory mechanisms of nitric oxide on the development of inflammation and pain. Furthermore, pathophysiological roles of nitration of protein by nitric oxide metabolites are also investigated. About the protein nitration on inflammation and pain, we have now performing the collaboration with Professor Ferid Murad, the Nobel Prize Laureate in 1998, in Texas University.
In addition to the main themes, various interesting themes such as “Cancer development and apoptosis”, “Stem cell differentiation”, “Transcription factors”, and “Novel protein functions” are investigated in our Department. We keep efforts to discover and clarify the new mechanisms on such various themes for new therapeutic applications.


Topics

We are performing many international collaborations. About the roles of nitric oxide and nitrotyrosine, we are collaborating with Professor Ferid Murad, Texas University, and Dr. Ka Bian, Shanghai University. In addition, we are also collaborating with Harvard University about the “Inflammation and Immunology”.

Topics