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Department of Oral and Maxillofacial Surgery 2

Department of Oral and Maxillofacial Surgery 2

We are teaching most oral diseases including odontogenic inflammation, oral cancer, malformation of lip and palate, deformity of jaw bones, trauma, diseases of oral mucosa, cystic lesions, atrophy of alveolar ridge, temporomandibular joint disease (TMD), and disorder of the salivary gland in School of Dentistry. Our major titles in the research and clinical fields in Graduate School of Dentistry are oral oncology and advanced method for oral and maxillofacial surgery.


Staff

position
name
E-mail (below@, dent.osaka-u.ac.jp)
Professor
Narikazu Uzawa
Associate Professor
Mitsuhiro Nakazawa
nakazawa@
Associate Professor
Soichi Iwai
s-iwai@
Assistant Professor
Itsurou Kato
katoitsu@
Assistant Professor
Hidetaka Shimizu
hshimizu@
Assistant Professor
Tomoaki Imai
Assistant Professor
Masakazu Hamada

Education

Major lecture contents for the students of School of Dentistry are oral oncology, principle of surgical treatment for oral diseases, practical method for tooth extraction, hematology associated with oral surgery, infection control, neurological disease, and implant surgery. In advanced sections we provide special lectures concerning the management of jaw bone fracture, surgical orthodontics, chemoradiotherapy of oral cancer, surgical treatment of TMD and treatment of ulcerative oral lichen planus.

Research Activities

Research Activities

The research themes in this laboratory include Wnt signaling pathway in oral carcinogenesis, oncolytic virotherapy with mutant type of herpes simplex virus type 1 (HSV-1), born neutron capture therapy (BNCT), molecular therapy directed to Ras families as the targets, and development of biomaterials for jaw bone defect.
Oncolytic virotherapy is a relatively novel method to destroy solid tumors, based on the cell killing effect of oncolytic HSV-1. In oral squamous cell carcinoma xenografts in nude mice, attenuated HSV-1 mutant could replicate and induce necrotic changes. Viral antigens are expressed in the tumor (right upper 2 figures). BNCT is a selective radiotherapy. The exposure of neuron beam to boron-10 produce radioactive particles with very short path lengths, so that only cancer cells that incorporate boron-10 can be destroyed. Neutron beam is delivered from Kyoto University Reactor (right middle figure). The oncogenic functions of small GTPases of the Ras family require posttranslational modification by geranylgeranyltransferase I (GGTase I). GGTase I is considered to be a molecular target in antitumor therapy. One of the inhibitors, GGTI-298, inhibits geranylgeranylation of the members of Ras family, RalA, RalB and RhoA, and inhibits the migration of oral squamous cell carcinoma cells. It also induces reorganization of actin cytoskeleton (right lower two figures).