講座からのメッセージ

　歯周病（歯槽膿漏）は、歯と歯ぐきの境目に棲みついた細菌が原因となって起こる病気です。歯周病にかかると歯を支えている組織（歯周組織）がしだいに失われていくため、歯がぐらぐらと揺れるようになり、最後には抜け落ちてしまいます。また、この歯周病はお口の中の病気で最も罹患率が高い病気であり、成人が歯を失う最大の理由となっています。
　口腔治療学講座は、この歯周病の予防と治療を担当する臨床講座です。

スタッフ

職名氏名E-mail（＠以下はosaka-u.ac.jp）
教授村上　伸也murakami.shinya.dent@
准教授北村　正博kitamura.masahiro.dent@
講師山下　元三yamashita.motozou.dent@
講師竹立　匡秀 
助教藤原　千春 
助教柏木　陽一郎
助教岩山　智明
助教三木　康史

講座のご案内

　口腔治療学講座は、歯周病の予防と治療を担当する臨床講座です。
　我々の講座では、歯周病の発症・進行のメカニズムの解明に向けた研究を行うとともに、その知見に基づいた新しい検査・診断法や治療法の研究開発を行っています。最近では、歯周病によって失われた歯周組織を再生させる治療法の開発を進めており、我々が新規に開発した治療法は国際的に高い評価を受けています。授業では、上記の研究成果も踏まえて、歯周病という病気の成り立ち、検査・診断法や治療法について解説するとともに、最新の研究論文の抄読や実際の患者さんの症例を紹介することを通じて、十分なディスカッションを行います。また、実習では、まずはマネキンを用いた模型実習を行って歯周病に対する基本的な治療手技を習得し、その上で実際の患者さんに接しての臨床実習へと進みます。この臨床実習では、包括的な歯周治療を経験するのみならず、歯周組織再生療法などの先端的診療の見学を行い、学習をさらに深めます。これらを通して、自ら “考える”能力を高めることを目標とした教育を行っています。

主な論文等（2019年以降の主要英文論文のみを抜粋）

  • Takedachi M, Kawasaki K, Sawada K, Sakura K, Murata M, Shimomura J, Kawakami K, Morimoto C, Miki K, Takeshita N, Iwayama T, Okura H, Matsuyama A, Saito M, Kitamura M, Murakami S. Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite. Cell Transplant. 2023 Jan-Dec 32.
  • Noda K, Lu SL, Chen S, Tokuda K, Li Y, Hao F, Wada Y, Sun-Wada GH, Murakami S, Fukuda M, Itoh T, Noda T. Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages. J Biol Chem. 2023 Oct;299(10):105191.
  • Fujihara C, Murakami K, Magi S, Motooka D, Nantakeeratipat T, Canela A, Tanaka RJ, Okada M, Murakami S. Omics-Based Mathematical Modeling Unveils Pathogenesis of Periodontitis in an Experimental Murine Model. J Dent Res. 2023 Oct 6.
  • Yamamoto Y, Fujihara C, Nantakeeratipat T, Matsumoto M, Noguchi T, Kitagawa M, Yamada S, Takata T, Kitaura H, Murakami S. CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress. J Periodontal Res. 2023 Sep 18.
  • Sawada K, Shimomura J, Takedachi M, Murata M, Morimoto C, Kawasaki K, Kawakami K, Iwayama T, Murakami S. Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts. J Periodontol. 2023 Jul 26.
  • Narukawa Y, Sugiyama N, Miura J, Yamashita R, Tominaga S, Izumi Y, Bamba T, Ishihama Y, Kashiwagi Y, Murakami S. Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium. J Periodontal Res. 2023 Aug;58(4):813-826.
  • Nagayasu-Tanaka T, Anzai J, Takedachi M, Kitamura M, Harada T, Murakami S. Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect. Regen Ther. 2023 Apr 22;23:84-93.
  • Nantakeeratipat T, Fujihara C, Nogimori T, Matsumoto M, Yamamoto T, Murakami S. Lysosomal acid lipase regulates bioenergetic process during the cytodifferentiation of human periodontal ligament cells. Biochem Biophys Res Commun. 2023 Jun 25;662:84-92.
  • Ikegami K, Yamashita M, Suzuki M, Nakamura T, Hashimoto K, Kitagaki J, Yanagita M, Kitamura M, Murakami S. Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue. Aging. 2023;15(5):1279–305.
  • Matsumoto M, Fujihara C, Nantakeeratipat T, Kitagaki J, Yamamoto Y, Yamada S, et al. Lipase-a single-nucleotide polymorphism rs143793106 is associated with increased risk of aggressive periodontitis by negative influence on the cytodifferentiation of human periodontal ligament cells. J Periodontal Res. 2023 Feb;58(1):175-183.
  • Iwayama T, Iwashita M, Miyashita K, Sakashita H, Matsumoto S, Tomita K, et al. Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament. Development. 2022;149
  • Kitamura M, Yamashita M, Miki K, Ikegami K, Takedachi M, Kashiwagi Y, Nozaki T, Yamanaka K, Masuda H, Ishihara Y, Murakami S. An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects. Regen Ther. 2022 Dec;21:104–13.
  • Iwayama T, Sakashita H, Takedachi M, Murakami S. Periodontal tissue stem cells and mesenchymal stem cells in the periodontal ligament. Jpn. Dent. Sci. Rev. 2022 Nov;58:172–8
  • Takedachi M, Shimabukuro Y, Sawada K, Koshimizu M, Shinada K, Asai H, Mizoguchi A, Hayashi Y, Tsukamoto A, Miyago M, Nishihara F, Nishihata T, Shimabukuro M, Kurakami H, Sato T, Hamazaki Y, Iwayama T, Fujihara C, Murakami S. Evaluation of periodontitis-related tooth loss according to the new 2018 classification of periodontitis. Sci. Rep. 2022 Jul 13;12(1):11893.
  • Yagi H, Takahata Y, Murakami T, Nakaminami Y, Hagino H, Yamamoto S, et al. Transcriptional regulation of FRZB in chondrocytes by Osterix and Msx2. J Bone Miner Metab. 2022;40: 723–734.
  • Iwayama T, Bhongsatiern P, Takedachi M, Murakami S. Matrix Vesicle-Mediated Mineralization and Potential Applications. J Dent Res. 2022;101:1554–1562.
  • Takedachi M, Yamamoto S, Kawasaki K, Shimomura J, Murata M, Morimoto C, Hirai A, Kawakami K, Bhongsatiern P, Iwayama T, Sawada K, Yamada S, Murakami S. Reciprocal role of PLAP-1 in HIF-1α-mediated responses to hypoxia. J. Periodontal Res. 2022 Jun;57(3):470–8.
  • Takedachi M, Sawada K, Sakura K, Morimoto C, Hirai A, Iwayama T, Shimomura J, Kawasaki K, Fujihara C, Kashiwagi Y, Miyake A, Yamada T, Okura H, Matsuyama A, Saito M, Kitamura M, Murakami S. Periodontal tissue regeneration by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells. Sci. Rep. 2022 May 17;12(1):8126
  • Fujihara C, Nantakeeratipat T, Murakami S. Energy Metabolism in Osteogenic Differentiation and Reprogramming: A Possible Future Strategy for Periodontal Regeneration. Frontiers in Dental Medicine . 2022;3.
  • Kataoka S, Kimura M, Yamaguchi T, Egashira K, Yamamoto Y, Koike Y, Ogawa Y, Fujiharu C, Namai T, Taguchi K, Takahashi M, Kameda A, Kasen T, Hano A, Kubota K, Sato M, Yamaga H, Nohara K, Shirasawa M, Sekine C, Fukuda M, Aoki A, Takeuchi Y, Mugiyama M, Mori K, Sawada K, Kashiwagi Y, Kitamura M, Hayashi T, Nakagawa T, Murakami S. A cross-sectional study of relationships between periodontal disease and general health: The Hitachi Oral Healthcare Survey. BMC Oral Health. 2021 Dec 15;21(1):644.
  • Morimoto C, Takedachi M, Kawasaki K, Shimomura J, Murata M, Hirai A, Kawakami K, Sawada K, Iwayama T, Murakami S. Hypoxia stimulates collagen hydroxylation in gingival fibroblasts and periodontal ligament cells. J. Periodontol. 2021 Nov;92(11):1635–45.
  • Tatsumi M, Yanagita M, Yamashita M, Hasegawa S, Ikegami K, Kitamura M, Murakami S. Long-term exposure to cigarette smoke influences characteristics in human gingival fibroblasts. J. Periodontal Res. 2021 Oct;56(5):951–63.
  • Kashiwagi Y, Aburaya S, Sugiyama N, Narukawa Y, Sakamoto Y, Takahashi M, Uemura H, Yamashita R, Tominaga S, Hayashi S, Nozaki T, Yamada S, Izumi Y, Kashiwagi A, Bamba T, Ishihama Y, Murakami S. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Sci. Rep. 2021 Sep 15;11(1):18398.
  • Yamada S, Tsushima K, Kinoshita M, Sakashita H, Kajikawa T, Fujihara C, Yuan H, Suzuki S, Morisaki T, Murakami S. Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling. Front. Physiol. 2021 Aug 11;12:715687.
  • Hasegawa S, Yanagita M, Tatsumi M, Yamashita M, Kitamura M, Murakami S. Aromatase inhibitor anastrozole modifies cellular functions in gingival fibroblasts and endothelial cells: possible periodontal complications of aromatase inhibitor treatment. J. Periodontal Res. 2021 Aug;56(4):828–36.
  • Miki K, Kitamura M, Hatta K, Kamide K, Gondo Y, Yamashita M, Takedachi M, Nozaki T, Fujihara C, Kashiwagi Y, Iwayama T, Takahashi T, Sato H, Murotani Y, Kabayama M, Takeya Y, Takami Y, Akasaka H, Yamamoto K, Sugimoto K, Ishizaki T, Masui Y, Rakugi H, Ikebe K, Murakami S. Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study. Sci. Rep. 2021 Jul 14;11(1):14436.
  • Takayama S-I, Murakami S. Efficacy of FGF-2 in Periodontal Regeneration in a Case of Severe Intrabony Defect and Furcation Involvement With 15-Month Follow-Up. Clin Adv Periodontics. 2021 Jun;11(2):74–9.
  • Yagi H, Fujihara C, Murakami S. Effects of oxidative stress-induced increases in Zn2+ concentrations in human gingival epithelial cells. J. Periodontal Res. 2021 Jun;56(3):512–22.
  • Ueda T, Iwayama T, Tomita K, Matsumoto S, Iwashita M, Bhongsatiern P, Sakashita H, Fujihara C, Takedachi M, Murakami S. Zbp1-positive cells are osteogenic progenitors in periodontal ligament. Sci. Rep. 2021 Apr 6;11(1):7514.
  • Kitamura M, Ikebe K, Kamide K, Gondo Y, Yamashita M, Takedachi M, Nozaki T, Fujihara C, Yamada S, Kashiwagi Y, Miki K, Iwayama T, Hatta K, Mihara Y, Kurushima Y, Takeshita H, Kabayama M, Oguro R, Kawai T, Akasaka H, Takeya Y, Yamamoto K, Sugimoto K, Ishizaki T, Arai Y, Masui Y, Takahashi R, Rakugi H, Maeda Y, Murakami S. Association of periodontal disease with atherosclerosis in 70-year-old Japanese older adults. Odontology. 2021 Apr;109(2):506–13.
  • Sakashita H, Yamada S, Kinoshita M, Kajikawa T, Iwayama T, Murakami S. Mice lacking PLAP-1/asporin counteracts high fat diet-induced metabolic disorder and alveolar bone loss by controlling adipose tissue expansion. Sci. Rep. 2021 Mar 2;11(1):4970.
  • Nakamura T, Yamashita M, Ikegami K, Suzuki M, Yanagita M, Kitagaki J, Kitamura M, Murakami S. Autophagy facilitates type I collagen synthesis in periodontal ligament cells. Sci. Rep. 2021 Jan 14;11(1):1291.
  • Nozawa A, Oshima H, Togawa N, Nozaki T, Murakami S. Development of Oral Care Chip, a novel device for quantitative detection of the oral microbiota associated with periodontal disease. PLoS One. 2020 Feb 28;15(2):e0229485.
  • Iwayama T, Okada T, Ueda T, Tomita K, Matsumoto S, Takedachi M, Wakisaka S, Noda T, Ogura T, Okano T, Fratzl P, Ogura T, Murakami S. Osteoblastic lysosome plays a central role in mineralization. Sci Adv. 2019 Jul;5(7):eaax0672.
  • Masumoto R, Kitagaki J, Fujihara C, Matsumoto M, Miyauchi S, Asano Y, Imai A, Kobayashi K, Nakaya A, Yamashita M, Yamada S, Kitamura M, Murakami S. Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis. J. Periodontal Res. 2019 Jun;54(3):199–206.
  • Fujihara C, Kanai Y, Masumoto R, Kitagaki J, Matsumoto M, Yamada S, Kajikawa T, Murakami S. Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation. J. Cell. Physiol. 2019 May;234(5):7149–60.