業績（≫1989年～2017年はこちら）
原著論文
Ikeda E, Yamaguchi M, Kawabata S. 2025: The human oral microbial consortium associated with periodontitis attenuates weight loss in dextran sulfate sodium-induced colitis. Gastro Hep Advances. (in press).
Li Y., Nakata M., Migita H., Matsumoto A., Oogai Y., Takebe K., Yamaguchi M., Okahashi N., Sumitomo T., Kawabata S. 2025: Identification of PilX, pilus component of Streptococcus sanguinis. J. Oral Biosci. (in press).
Takemoto N., Ogura K., Gao Y., Okuno R., Yamaguchi M., Hirose Y., Ono M., Kawabata S., Ikebe T., Hamabata T., Miyoshi-Akiyama T. 2025: GAS-J, a user-friendly browser application for genome assembly, emm-typing, MLST typing, and virulence factor gene detection of Streptococcus pyogenes. Microbiol. Immunol. (in press).
Nakayama Y., Sasai M., Kuratani A., Okamoto M., Okuzaki D., Yamamoto K., Ono C., Yamaguchi M., Kawabata S., Shinjyo N., Okabe Y., Matsuura Y., Ato M., Yamamoto M. 2025: Targeted labeling and depletion of alveolar macrophages using VeDTR mouse technology. iScience. 28(3). 111975.
Gong W., Ono M., Yamaguchi M., Motooka D., Hirose Y., Higashi K., Kobayashi M., Ikeda E., Sumitomo T., Okuno R., Yamaguchi T., Kawahara R., Otsuka H., Nakanishi N., Kazawa Y., Nakagawa C., Yamaguchi R., Sakai H., Matsumoto Y., Ikebe T., Kawabata S. 2025: A comprehensive analysis of antimicrobial resistance of clinical emm89 Streptococcus pyogenes in Japan. JAC Antimicrob Resist. 7(1):dlaf017.
Ikeda E., Yamaguchi M., Ono M., Kawabata S. 2024: In vitro acid resistance of pathogenic Candida species in stimulated gastric fluid. Gastro Hep Advances. 4(4):10059.
Takahara Y., Sumitomo T., Kono M., Takemura M., Akamatsu Y., Hirose Y, Yamaguchi M., Nakata M., Hotomi M., Kawabata S. 2024: Pneumolysin Contributes to Dysfunction of Nasal Epithelial Barrier for Promotion of Pneumococcal Dissemination into Brain Tissue. mSphere. 9(10):e0065524.
Hirose Y., Zielinski DC., Poudel S., Rychel K., Baker JL., Toya Y., Yamaguchi M., Heinken A., Thiele I., Kawabata S., Palsson BO., Nizet V. 2024: A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes. mSystems, 9:e00736-24.
Ikeda E., Yamaguchi M., Kawabata S. 2024: Gut microbiota-mediated alleviation of dextran sulfate sodium-induced colitis in mice. Gastro Hep Advances. 3(4):461-470.
Takebe K., Suzuki M., Sangawa T., Kreikemeyer B., Yamaguchi M., Uzawa N., Sumitomo T., Kawabata S., Nakata M. 2023: Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms. Arch. Microbiol. 206(1):4.
Hirose Y., Poudel S., Sastry AV., Rychel K., Lamoureux CR., Szubin R., Zielinski CD., Lim HG., Menon DN., Bergsten H., Uchiyama S., Hanada T., Kawabata S., Palsson BO., Nizet V. 2023: Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins. mSystems. 8:e0024723.
Kubota S., Nakata M., Hirose Y., Yamaguchi M., Kreikemeyer B., Uzawa N., Sumitomo T., Kawabata S. 2023: Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of mRNA level of transcriptional regulator. Microbiol. Immunol.,67(7):319-333.
Akamatsu Y., Akagi T., Sumitomo T., Takahara Y., Akiyama S., Kawabata S., Akashi M. 2023: Construction of Human Three-Dimensional Lung Model Using Layer-by-Layer Method. Tissue Eng Part C Methods. 29: 95-102.
Okahashi N., Sumitomo T., Nakata M., Kuwata H., Kawabata S. 2022: Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2 production. PLOS One, 17: e0276293.
Okamoto M., Matsumoto S., Moriyama K., Huang H., Watanabe M., Miura J., Sugiyama K., Hirose Y., Manabu M., Kuriki N., Leprince J.G., Takahashi Y., Kawabata S., Hayashi M. 2022: Biological evaluation of the effect of root canal sealers using a rat model. Pharmaceutics, 14: 2038.
Bergmann R., Gulotta G., Andreoni F., Sumitomo T., Kawabata S., Zinkernagel A.S., Chhatwal G.S., Nizet V., Rohde M., Uchiyama S. 2022: The group A Streptococcus interleukin-8 protease SpyCEP promotes bacterial intracellular survival by evasion of autophagy. Infect. Microb. Dis., 4: 116.
Hirose Y., Kolesinski P., Hiraoka M., Uchiyama S., Zurich R.H., Kumaraswamy M., Bjanes E., Ghosh P., Kawabata S., Nizet V. 2022: Contribution of Streptococcus pyogenes M87 protein to innate immune resistance and virulence. Microb. Pathog., 169: 105636.
Takemura M., Yamaguchi M., Kobayashi M., Sumitomo T., Hirose Y., Okuzaki D., Ono M., Motooka D., Goto K., Nakata M., Uzawa N., Kawabata S. 2022: Pneumococcal BgaA promotes host organ bleeding and coagulation in a mouse sepsis model. Front. Cell. Infect. Microbiol., 12: 844000.
Wu Z.Y., Campeau A., Liu C.H., Gonzalez D.J., Yamaguchi M., Kawabata S., Lu C.H., Lai C.Y., Chiu H.C., Chang Y.C. 2021: Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome. Virulence, 12: 2633-2647.
Sumitomo T., Nakata M., Nagase S., Takahara Y., Honda-Ogawa M., Mori Y., Akamatsu Y., Yamaguchi M., Okamoto S., Kawabata S. 2021: GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection. mBIO., 12: e0326920.
Hirose Y., Yamaguchi M., Sumitomo T., Nakata M., Hanada T., Okuzaki D., Motooka D., Mori Y., Kawasaki H., Coady A., Uchiyama S., Hiraoka M., Zurich R.H., Amagai M., Nizet V., Kawabata S. 2021: Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep., 34: 108924.
Kataoka K., Kawabata S., Koyanagi K., Hashimoto Y., Miyake T., Fujihashi K. 2021: Respiratory FimA-specific secretory IgA antibodies upregulated by DC-targeting nasal double DNA adjuvant are essential for elimination of Porphyromonas gingivalis. Front. Immunol., 12: 634923.
Yamaguchi M., Myo Win H. P., Higashi K., Ono M., Hirose Y., Motooka D., Okuzaki D., Aye M. M., Htun M. M., Thu H. M., Kawabata S. 2021: Epidemiological Analysis of Pneumococcal Strains Isolated at Yangon Children’s Hospital in Myanmar via Whole-genome Sequencing-based Methods. Microb. Genomics, 7: 000523.
Hirose Y., Yamaguchi M., Takemoto N., Miyoshi-Akiyama T., Sumitomo T., Nakata M., Ikebe T., Hanada T., Yamaguchi T., Kawahara R., Okuno R., Otsuka H., Matsumoto Y., Terashima Y., Kazawa Y., Nakanishi N., Uchida K., Akiyama Y., Iwabuchi K., Nakagawa C., Yamamoto K., Nizet V., Kawabata S. 2020: Genetic characterization of Streptococcus pyogenes emm89 strains isolated in Japan from 2011 to 2019. Infect. Microbe Dis., 2(4): 160-166.
Yamaguchi M., Takemura M., Higashi K., Goto K., Hirose Y., Sumitomo T., Nakata M., Uzawa N., Kawabata S. 2020: Role of BgaA as a pneumococcal virulence factor elucidated by molecular evolutionary analysis. Front Microbiol., 11: 582437.
Otsuki N, Wada M, Yamaguchi M, Kawabata S, Maeda Y, Ikebe K. 2020: Evaluation of decontamination methods of oral biofilms formed on screw-shaped, rough and machined surface implants: an ex vivo study. Int J Implant Dent. 6(1): 18.
Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, Kawabata S. 2020: Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death. PLoS One. 15(4): e0231101.
Okamoto M, Matsumoto S, Sugiyama A, Kanie K, Watanabe M, Huang H, Ali. M, Ito Y, Miura J, Hirose Y, Uto K, Ebara M, Kato R, Yamawaki-Ogata A, Narita Y, Kawabata S, Takahashi Y, Hayashi M. 2020: Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair. Polymers (Basel). 12: 937.
Nakata M, Kawabata S. 2020: Detection of Fibronectin-Binding Proteins of Streptococcus pyogenes Using Ligand Blot Analysis. Methods Mol Biol. 113: 173-189.
Nakata M, Sumitomo T, Patenge N, Kreikemeyer B, Kawabata S. 2020: Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency. Mol Microbiol. 113: 173-189.
Sankar S, Yamaguchi M, Kawabata S, Ponnuraj K. 2020: Streptococcus pneumoniae surface adhesin PfbA exhibits host specificity by binding to human serum albumin but not bovine, rabbit and porcine serum albumins. Protein J. 39: 1-9.
Okamoto M, Manahil A, Komichi S, Watanabe N, Huang H, Ito Y, Miura J, Hirose Y, Mizuhira M, Takahashi Y, Okuzaki D, Kawabata S, Imazato S, Hayashi M. 2019: Surface pre-reacted glass filler contribute to tertiary dentin formation through a mechanism different than that of hydraulic calcium-silicate cement. J Clin Med, 8: 1440.
Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S. 2019: Streptococcus pyogenes transcriptome changes in inflammatory environment of necrotizing fasciitis. Appl Environ Microbiol, 85: e01428-19.
Yamaguchi M, Hirose Y, Takemura M, Ono M, Sumitomo T, Nakata M, Terao Y, Kawabata S. 2019: Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. Front Cell Infect Microbiol, 9: 301.
Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y. 2019: Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria that predominate in the oral cavity and upper airways. Microbiol Immunol, 63: 213-222.
Yamaguchi, M., Goto, K., Hirose, Y., Yamaguchi, Y., Sumitomo, T., Nakata, M., Nakano K., Kawabata, S. 2019: Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae.Communications Biology, 2: 96.
Hirose, Y., Yamaguchi, M., Goto, K., Sumitomo, T., Nakata, M., Kawabata, S. 2018: Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis. Virulence, 9: 1576-1587.
Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., Terao, Y. 2018: Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Microbiol Immunol, 62: 617-623.
Radhakrishnan, D., Yamaguchi, M., Kawabata, S., Ponnuraj, K. 2018: Streptococcus pneumoniae surface adhesin PfbA and its interaction with erythrocytes and hemoglobin. Int J Biol Macromol, 120: 135-143.
Ogawa, T., Honda-Ogawa, M., Ikebe, K., Notomi, Y., Iwamoto, Y., Shirobayashi, I., Hata, S., Kibi, M., Masayasu, S., Sasaki, S., Kawabata, S., Maeda, Y. 2017:Characterizations of oral microbiota in elderly nursing home residents with diabetes. J Oral Sci, 59: 549-555.
Domon, H., Nagai, K., Maekawa, T., Oda, M., Yonezawa, D., Takeda, W., Hiyoshi, T., Tamura, H., Yamaguchi, M., Kawabata, S., Terao, Y. 2018:Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia. Front Immunol, 9: 732.
Hirose, Y., Funahashi, Y., Matsukawa, Y., Majima, T., Yamaguchi, M., Kawabata, S., Gotoh, M., Yamamoto, T. 2018: Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals. Cytotherapy, 20: 589-591.
Nagai, K., Domon, H., Maekawa, T., Oda, M., Hiyoshi, T., Tamura, H., Yonezawa, D., Arai, Y., Yokoji, M., Tabeta, K., Habuka, R., Saitoh, A., Yamaguchi, M., Kawabata, S., Terao, Y. 2018: Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell Immunol, 325: 14-22.
Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., Terao, Y. 2018: Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Microbes Infect, 20: 9-18.
Sumitomo, T., Mori, Y., Nakamura, Y., Honda-Ogawa, M, Nakagawa, S., Yamaguchi, M., Matsue, H., Terao, Y., Nakata, M., Kawabata, S. 2018: Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection, Front Cell Infect Microbiol, 8: 10.
Ogawa, T., Hirose, Y., Ogawa-Honda, M., Sugimoto, M., Sasaki, S., Kibi, M., Kawabata, S., Ikebe, K., Maeda, Y. 2018: Composition of salivary microbiota in elderly subjects, Sci Rep, 8: 414.
総説
山口雅也，川端重忠．2024．基礎研究から見た化膿レンサ球菌による病態形成機構と宿主の防御機構．医学のあゆみ．288 (10): 869-874．
Okahashi N., Nakata M., Kuwata H., Kawabata S. 2022: Oral mitis group streptococci: A silent majority in our oral cavity. Microbiol Immunol., 66: 539-551.
Okahashi N, Sumitomo T, Nakata M, Kawabata S. 2022: Secondary streptococcal infection following influenza. Microbiol Immunol., 66: 253-263.
山口雅也，川端重忠．2022．肺炎球菌の種の壁を超える進化機構 ～肺炎球菌は口腔レンサ球菌の遺伝子を取り込んで耐性化する～．日本歯科医師会雑誌．75 (3)：in press．
住友倫子，川端重忠．2022．インフルエンザに合併する細菌性肺炎の重要性．歯界月報．848：1-6．
後藤花奈，山口雅也，川端重忠．2019．Streptococcus pneumoniaeのコリン結合タンパク質が感染成立に果たす役割．大阪大学歯学雑誌．64（1）：5-7．
山口雅也，川端重忠．2018．病原レンサ球菌の感染過程における莢膜糖鎖と糖鎖分解酵素の役割．生化学．公益社団法人 日本生化学会．90: 80-83.
著書
Yamaguchi M., Takemura M., Higashi K., Goto K., Hirose Y., Sumitomo T., Nakata M., Uzawa N., Kawabata S. 2020: Role of BgaA as a pneumococcal virulence factor elucidated by molecular evolutionary analysis., In Evolutionary Mechanisms of Infectious Diseases. edited by Gu J., Zhou Z., Wang Y. Lausanne: Frontiers Media SA. 40-50.
川端重忠．2021．微生物の歴史と発展，2-6頁．口腔微生物学・免疫学 第5版，川端重忠・小松澤均・大原直也・寺尾豊 編，医歯薬出版．
川端重忠．2021．微生物の基礎，7-9頁．口腔微生物学・免疫学 第5版，川端重忠・小松澤均・大原直也・寺尾豊 編，医歯薬出版．
住友倫子，川端重忠．2021．真菌，27-36頁．口腔微生物学・免疫学 第5版，川端重忠・小松澤均・大原直也・寺尾豊 編，医歯薬出版．
中田匡宣，川端重忠．2021．微生物の遺伝学，40-45頁．口腔微生物学・免疫学 第5版，川端重忠・小松澤均・大原直也・寺尾豊 編，医歯薬出版．
山口雅也，川端重忠．2021．グラム陽性球菌と感染症，140-147頁．口腔微生物学・免疫学 第5版，川端重忠・小松澤均・大原直也・寺尾豊 編，医歯薬出版．
山口雅也，川端重忠．2021．4. 微生物，209-221頁．イラストでわかる歯科医学の基礎 第4版，村上秀明，西村康，天野修 監修，永末書店．
住友倫子，川端重忠．2021．5. 感染，222-227頁．イラストでわかる歯科医学の基礎 第4版，村上秀明，西村康，天野修 監修，永末書店．
山口雅也，川端重忠．2021．7. 口腔感染症，238-244頁．イラストでわかる歯科医学の基礎 第4版，村上秀明，西村康，天野修 監修，永末書店．
山口雅也，川端重忠．2020．第III編 第3章 肺炎と微生物叢，158-164頁．ヒト常在菌叢と生理機能・全身疾患，落合邦康 監修，シーエムシー出版．